Initial lung inflation - "erectile force" by filling of the capillaries

    In one experiment, Jäykkä placed un-inflated fetal lungs in a jar covered
    with a rubber membrane to simulate movement of the diaphragm.  An
    air-inlet tube was connected with the trachea, and a tube for injection of
    fluid inserted into the pulmonary artery of one lung.  The lung with fluid
    injected into the pulmonary artery promptly filled with air following
    movement of the rubber diaphragm.  When this lung was then removed
    from the jar, it was found to float in water.  The other lung did not inflate,
    remained dense, and sank in water.

    Under the microscope, the alveoli of the lung injected with fluid were fully
    opened, whereas only partial opening had occurred in the other lung.

    Jäykkä (1958) reported on the appearance of lungs of pre-term and full-
    term infants who died before or shortly after birth, and described two
    kinds of expansion: (1) that characteristic of inflation by air only, and
    (2) expansion by what he termed "erectile force." [3].

    Inflation with air led to abnormal expansion in an irregular pattern with
    large areas of lung remaining uninflated while other areas appeared
    overinflated.  India ink injections into the pulmonary artery revealed lack
    of circulation to areas that failed to inflate. India ink also revealed a
    bypass circuit, remnant of prenatal circulation.  Infants with irregular lung
    expansion of this type also frequently had hyaline membranes and fit
    descriptions in the literature of "congenital alveolar dysplasia."            home
A decade online (2000-2010)

New Decade
Dr. Morley
Neonatal transition
Dr. Hutchon

Instrument of harm
>>The first breath
Postnatal placental circulation

Comments for the IACC


Conrad Simon (1963-1995)
Pictures (Conrad & his brothers)
Traumatic birth
Death in a group home

© Copyright 1999-2010
Eileen Nicole Simon
Conrad Simon Memorial Research Initiative
<< 22  >>