A decade online (2000-2010)
Instrument of harm
>>The first breath
Postnatal placental circulation
Comments for the IACC
Conrad Simon (1963-1995)
Pictures (Conrad & his brothers)
Death in a group home
© Copyright 1999-2010
Eileen Nicole Simon
Conrad Simon Memorial Research Initiative
Exhalation before the first breath?
movements of the diaphragm in the newborn infant – an initial respiratory
effort made immediately following birth in the healthy child. Jäykkä's
experiments included simulation of diaphragm movement, along with
ventilation of one lung and ventilation plus fluid filling of the capillary bed of
Jäykkä used the un-inflated (atelectatic) lungs of fetuses that had died before
birth. Injection of fluid (macrodex solution) into the pulmonary artery of one
lung resulted in expansion of the alveoli of that lung. Expansion occurred first
in the most distal alveoli, with expansion in three stages of the more proximal
alveoli toward the center of the lung – before initial function of the bronchial
airway the alveoli deepest in the lungs were first to inflate! Consider the
added effect of carbon dioxide released by hemoglobin to be exhaled from
these newly opened alveoli.
An initial exhalation may precede the first breath.
Carbon dioxide from the circulation may perhaps initiate inflation of the
alveoli. If circulation to and from the placenta is abruptly clamped off, where
will the blood needed for the lungs come from? The lungs take priority at
birth. If the blood needed is drained from the brain, the result may be the
kind of ischemic damage found in monkeys subjected to asphyixa at birth --
and with an Apgar score of 10.