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    Discussion point 7

    7.  Evidence that synthetic vitamin K and sulfisoxazole antibiotic are toxic to the
    blood-brain barrier [58-67]

    Note: Natural vitamin K is fat soluble.  Synthetic versions are water soluble,
    thus could be given by injection.  Robertson pointed out that vitamin K became
    the second standard treatment for all newborn infants: “The prophylactic use
    of vitamin K in newborns began in the early 1940s and was the second routine
    pharmacological treatment of newborn infants; the first being the use of silver
    nitrate to prevent ophthalmia neonatorum.” [63, p53]

    Comment:  Discovery of the toxicity of synthetic vitamin K occurred at the same
    time that autoradiography revealed high blood-flow and metabolism in the
    inferior colliculi and other subcortical structures affected in kernicterus.  Why
    have these elegant studies of brain activity been so neglected?   Vitamin K
    continues to be part of accepted practice even though its routine
    administration to all newborns continues to be controversial, and rightfully so
    [62, 63].
home (2000-2010)
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IACC discussion
IACC mandate
Errors in Neonatology

Discussion points
Supporting evidence

The auditory system
Final common pathway
Blood-brain barrier
>Toxic injury
Brain maturation

Speech comprehension
Birth complications

Figures/ tables
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