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    Discussion point 8

    8.  Evidence that damage of subcortical sites in the perinatal period leads to
    disruption of normal maturation of the cerebral cortex [68].

    Sites of injury found in monkeys subjected to asphyxia at birth are listed in
    table 2.  Sites of secondary growth failure are listed in table 3.

    Note:  Faro and Windle examined the brains of monkeys kept alive for many
    months or years after being subjected to asphyxia at birth.  They noted:

    “structural changes sequential to the initial asphyxial lesions . . .
    It was difficult to separate the primary effects of asphyxia from
    these later atrophic changes in some regions . . .” [68, p41].

    “Some of these regions, such as the frontal and parietal cortex,
    will be recognized as locations normally receiving the terminations
    of tracts destroyed by the primary lesions. . . .  Extensive primary
    damage by asphyxia at birth led to a reduction in amount of white
    matter, as in the corpus callosum . . .  All the animals had severe
    brain damage, but some were worse off than others.” [68, p43]
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